Hongo M
Department of Comprehensive Medicine and Psychosomatic Medicine, Tohoku University School of Medicine, Sendai 980-8574, Japan.
Aliment Pharmacol Ther. 2004 Dec;20 Suppl 8:50-4. doi: 10.1111/j.1365-2036.2004.02230.x.
In Asia, oesophageal diseases, such as Barrett's oesophagus and oesophageal carcinoma, have traditionally been less common than in America and Europe. In recent years, however, the number of reported cases of these conditions in Japan has increased. Two large prospective studies, the Sendai Barrett's Esophagus Study (S-BEST) and the Far East Study (FEST), on the geographic prevalence of Barrett's oesophagus, have recently investigated the epidemiology of Barrett's oesophagus in Japan. Results from both studies showed that overall prevalence of the condition is lower than in the West: 0.9-1.2% in Japan compared with 1-4% in Europe and 5-12% in USA. Similar to the situation in the West, the condition was shown to be most prevalent in elderly male patients and least prevalent in patients with Helicobacter pylori. Adenocarcinoma of the oesophagus is still rare in this region, although there has been an increase in the annual death rate from 3.7 (1960) to 6.9 (1995) per 100,000 population. Risk factors for oesophageal carcinoma include a strong association with the prevalence of gastro-oesophageal reflux disease (GERD). With the increasing prevalence of GERD in the Japanese population, continued surveillance of changes in the epidemiology of columnar-lined oesophagus (a precursor of Barrett's oesophagus), Barrett's oesophagus and adenocarcinoma of the oesophagus is strongly recommended.
在亚洲，诸如巴雷特食管和食管癌等食管疾病传统上不如在美国和欧洲常见。然而，近年来，日本报告的这些疾病病例数有所增加。两项关于巴雷特食管地理患病率的大型前瞻性研究，即仙台巴雷特食管研究（S-BEST）和远东研究（FEST），最近对日本巴雷特食管的流行病学进行了调查。两项研究结果均显示，该病的总体患病率低于西方：日本为0.9%-1.2%，而欧洲为1%-4%，美国为5%-12%。与西方情况类似，该病在老年男性患者中最为普遍，而在幽门螺杆菌感染者中最为少见。食管腺癌在该地区仍然罕见，尽管每10万人的年死亡率已从1960年的3.7上升至1995年的6.9。食管癌的危险因素包括与胃食管反流病（GERD）患病率密切相关。鉴于GERD在日本人群中的患病率不断上升，强烈建议持续监测柱状上皮化生食管（巴雷特食管的前驱病变）、巴雷特食管和食管腺癌的流行病学变化。
