Tsvettsik V E, Rodoman V E, Zhmurov V A, Krylov V I, Lerner G Ia, Berdichevskiĭ B A, Kazeko N I, Ovchinnikov A A
Urol Nefrol (Mosk). 1994 Mar-Apr(2):16-9.
It is established that active pyelonephritis and operative stress are accompanied with structural and functional changes in erythrocytic membranes: cholesterol and its ethers rose in quantity as well as difficulty oxidized phospholipids, cation adenosine triphosphatase activity changed. Being nonspecific, these changes seemed more pronounced in the active phase of chronic pyelonephritis. Minor structural rearrangement of membrane lipids in surgical patients indicated uneventful postoperative period. It is suggested that bacterial inflammation in the kidneys and urinary tracts may be related to the above shifts. The adjuvant use of dimephosphone produced a clear-cut membrane-stabilizing effect clinically reflected by reduced inflammation and improved renal function.
现已证实，急性肾盂肾炎和手术应激会伴随红细胞膜的结构和功能变化：胆固醇及其醚类的含量增加，同时难氧化磷脂增加，阳离子腺苷三磷酸酶活性发生改变。这些变化是非特异性的，在慢性肾盂肾炎的活动期似乎更为明显。手术患者膜脂质的轻微结构重排表明术后恢复顺利。提示肾脏和尿路的细菌性炎症可能与上述变化有关。二膦酸盐的辅助使用产生了明显的膜稳定作用，临床上表现为炎症减轻和肾功能改善。
