Neprina G S, Panteleeva E S, Vatin O E, Kariakin O B
Urol Nefrol (Mosk). 1994 Mar-Apr(2):34-8.
A beneficial effect of bestatin used as adjuvant in the course of chemo- and radiotherapy of local cancer of the bladder manifested itself as a reduction of postradiation immunosuppression: increased count of T mu-helper/inductors and T gamma-suppressors/killers, enhancement of neutrophil phagocytic activity. Bestatin recovers radiation-impaired immune system by inhibition of T gamma-suppressor killers and their precursors generation, of endogenic regulators suppressive activity, normalization of T-lymphocyte and natural killer activity, stimulation of B-lymphocyte recovery.
在膀胱癌局部化疗和放疗过程中,作为佐剂使用的贝司他汀的有益作用表现为辐射后免疫抑制的减轻:Tμ辅助/诱导细胞和Tγ抑制/杀伤细胞数量增加,中性粒细胞吞噬活性增强。贝司他汀通过抑制Tγ抑制性杀伤细胞及其前体的产生、内源性调节因子的抑制活性、使T淋巴细胞和自然杀伤细胞活性正常化以及刺激B淋巴细胞恢复来恢复受辐射损害的免疫系统。