Panteleeva E S, Neprina G S, Vatin O E, Kariakin O B, Safiullin K N
Urol Nefrol (Mosk). 1997 Mar-Apr(2):29-32.
The authors consider general immunological effects of intravesical BCG vaccine as an independent method of immunotherapy of superficial cancer of the bladder (CB). 27 patients (15 males and 12 females, mean age 57 years) with a recurrence of superficial CB (T1-2N0M0) were treated. The patients had undergone transurethral or transvesical bladder resection and combined therapy. Intravesical immunotherapy of CB recurrence with BCG vaccine induced persistent changes in the immune system: stimulate lymphocyte activity and phagocytic activity of neutrophils, T-cell function, normalizes function of endogenic suppressors, increases the amount of IgM and CIC. Repeat courses of the vaccine maintain the above immunological effects for a long time.
作者将膀胱内卡介苗疫苗的一般免疫效应视为浅表性膀胱癌（CB）免疫治疗的一种独立方法。对27例浅表性CB复发（T1-2N0M0）患者（15例男性和12例女性，平均年龄57岁）进行了治疗。这些患者均接受了经尿道或经膀胱膀胱切除术及联合治疗。用卡介苗疫苗对CB复发进行膀胱内免疫治疗可引起免疫系统的持续变化：刺激淋巴细胞活性和中性粒细胞的吞噬活性、T细胞功能，使内源性抑制因子功能正常化，增加IgM和循环免疫复合物（CIC）的量。重复使用该疫苗疗程可长期维持上述免疫效应。
