Artificial neural networks for the electrocardiographic diagnosis of healed myocardial infarction.

Artificial neural networks are computer-based expert systems that learn by example, in contrast to the currently used rule-based electrocardiographic interpretation programs. For the purpose of this study, 1,107 electrocardiograms (ECGs) from patients who had undergone cardiac catheterization were used to train and test neural networks for the diagnosis of myocardial infarction. Different combinations of QRS and ST-T measurements were used as input to the neural networks. In a learning process, the networks automatically adjusted their characteristics to correctly diagnose anterior or inferior wall myocardial infarction from the ECG. Two thirds of the ECGs were used in this process. Thereafter, the performance of the networks was studied in a separate test set, using the remaining third of the ECGs. The results from the networks were also compared with that of conventional electrocardiographic criteria. The sensitivity for the diagnosis of anterior myocardial infarction was 81% for the best network and 68% for the conventional criteria (p < 0.01), both having a specificity of 97.5%. The corresponding sensitivities of the network and the criteria for the diagnosis of inferior myocardial infarction were 78% and 65.5% (p < 0.01), respectively, compared at a specificity of 95%. The results indicate that artificial neural networks may be of interest in the attempt to improve computer-based electrocardiographic interpretation programs.