Coibion M, Autier P, Vandam P, Delobelle A, Huet F, Hertens D, Vosse M, Andry M, De Sutter P, Heimann R
Jules Bordet Institute, Brussels, Belgium.
Br J Cancer. 1994 Jul;70(1):125-8. doi: 10.1038/bjc.1994.260.
The characteristics of cervicography and the Papanicolaou smear test have been compared for the detection of cervix lesions classified as CIN I or more. A total of 4,015 women were entered into the study. The sensitivity of cervicography is significantly higher (McNemar test, P < 0.0001), but its specificity remains significantly lower (McNemar test, P < 0.0001), and its higher sensitivity does not apply to lesions classified as CIN II or more (high-grade lesions). Hence, if patients with a positive screen result are to be referred for colposcopy-biopsy, cervicography is not a suitable alternative to the smear test for the screening of cervical cancer. However, cervicography can be envisaged as a complementary tool to the smear test because of (a) its higher capability to detect high-grade lesions among women less than 35 years old and (b) its potential superiority in following low-grade lesions. It may also serve as a tool for quality assurance audit of the smear test.
为了检测分类为CIN I或更高等级的宫颈病变,对宫颈造影和巴氏涂片检查的特征进行了比较。共有4015名女性参与了这项研究。宫颈造影的敏感性显著更高(McNemar检验,P<0.0001),但其特异性仍然显著更低(McNemar检验,P<0.0001),并且其较高的敏感性不适用于分类为CIN II或更高等级的病变(高级别病变)。因此,如果筛查结果呈阳性的患者要被转诊进行阴道镜活检,对于宫颈癌筛查而言,宫颈造影并非巴氏涂片检查的合适替代方法。然而,宫颈造影可被视为巴氏涂片检查的一种补充工具,原因在于:(a)其在检测35岁以下女性高级别病变方面能力更强;(b)其在追踪低级别病变方面可能具有优势。它还可作为巴氏涂片检查质量保证审核的一种工具。