Verbeek A L, Van den Ban M C, Hendriks J H
Department of Social Medicine, Nijmegen University, The Netherlands.
Br J Cancer. 1991 Feb;63(2):261-4. doi: 10.1038/bjc.1991.61.
Current proposals for a monitoring and evaluation system in breast cancer screening programmes focus on mortality reduction. Here emphasis is laid on the prevention of too high a number of false-positive screening results, i.e. no subsequent demonstration of malignancy. By comparing the specificity of the screening test, the positive predictive value and the detection rate with reference values, the screening performance can be measured in a very early phase of the programme, even before the registration results on interval cancers become available. The proposed average reference values for the first screening round are 99.2%, 40% and 5.4/1000, respectively. Measures specifically for the age groups 45-49, 50-59 and 60-69 will be given, thus allowing improvements to be made if necessary.
当前乳腺癌筛查项目监测与评估系统的提议聚焦于降低死亡率。这里重点在于防止出现过多假阳性筛查结果,即后续未证实为恶性肿瘤的情况。通过将筛查试验的特异性、阳性预测值和检出率与参考值进行比较,即使在间隔期癌症登记结果可用之前,也能在项目的非常早期阶段衡量筛查性能。首轮筛查提议的平均参考值分别为99.2%、40%和5.4/1000。将给出针对45 - 49岁、50 - 59岁和60 - 69岁年龄组的具体措施,从而在必要时进行改进。