大鼠多聚泛素mRNA的核苷酸序列与表达
Nucleotide sequence and expression of the rat polyubiquitin mRNA.
作者信息
Hayashi T, Noga M, Matsuda M
机构信息
Department of Biochemistry, Jikei University School of Medicine, Tokyo, Japan.
出版信息
Biochim Biophys Acta. 1994 Jun 21;1218(2):232-4. doi: 10.1016/0167-4781(94)90020-5.
Two polyubiquitin clones have been isolated from a rat brain cDNA library. Clone 22B1 contained four repetitive ubiquitin in tandem. Clone 19A2 coded ten complete repetitive ubiquitin followed by the first 20 amino acids of the previous repetitive ubiquitin and a distinct peptide. These clones were rat homologues for human UbB and UbC gene families, respectively. 1.2 kb UbB transcript, as well as 2.8 kb and 3.2 kb UbC transcripts, were widely expressed in the various rat tissues.
从大鼠脑cDNA文库中分离出了两个多聚泛素克隆。克隆22B1包含四个串联的重复泛素。克隆19A2编码十个完整的重复泛素，接着是前一个重复泛素的前20个氨基酸和一个独特的肽段。这些克隆分别是人类UbB和UbC基因家族的大鼠同源物。1.2 kb的UbB转录本以及2.8 kb和3.2 kb的UbC转录本在大鼠的各种组织中广泛表达。
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