Stein D G, Glasier M M, Hoffman S W
Brain Research Laboratory, Rutgers University, Newark, NJ 07102.
J Neural Transplant Plast. 1993 Jul-Sep;4(3):227-37. doi: 10.1155/NP.1993.227.
It is only within the last ten years that research on treatment for central nervous system (CNS) recovery after injury has become more focused on the complexities involved in promoting recovery from brain injury when the CNS is viewed as an integrated and dynamic system. There have been major advances in research in recovery over the last decade, including new information on the mechanics and genetics of metabolism and chemical activity, the definition of excitotoxic effects and the discovery that the brain itself secretes complex proteins, peptides and hormones which are capable of directly stimulating the repair of damaged neurons or blocking some of the degenerative processes caused by the injury cascade. Many of these agents, plus other nontoxic naturally occurring substances, are being tested as treatment for brain injury. Further work is needed to determine appropriate combinations of treatments and optimum times of administration with respect to the time course of the CNS disorder. In order to understand the mechanisms that mediate traumatic brain injury and repair, there must be a merging of findings from neurochemical studies with data from intensive behavioral testing.
直到最近十年，当把中枢神经系统视为一个整合的动态系统时，关于中枢神经系统损伤后恢复治疗的研究才更加聚焦于促进脑损伤恢复所涉及的复杂性。在过去十年中，恢复研究取得了重大进展，包括关于新陈代谢和化学活动的机制与遗传学的新信息、兴奋性毒性作用的定义，以及发现大脑自身会分泌复杂的蛋白质、肽和激素，这些物质能够直接刺激受损神经元的修复或阻断损伤级联反应导致的一些退行性过程。许多这些物质，加上其他无毒的天然物质，正在作为脑损伤的治疗方法进行测试。需要进一步开展工作，以确定针对中枢神经系统疾病病程的合适治疗组合和最佳给药时间。为了理解介导创伤性脑损伤和修复的机制，神经化学研究的结果必须与密集行为测试的数据相结合。
