Feeney D M, Sutton R L
Crit Rev Neurobiol. 1987;3(2):135-97.
Considerable attention has recently been focused on the development of pharmacotherapies for promotion of recovery of function after brain injury. This article reviews both animal and human experimentation in two areas which appear to have considerable clinical applicability in the very near future for promoting recovery: drug manipulation of neurotransmitter systems and administration of gangliosides. Since the most important problem after brain injury is restoration of lost behavioral capabilities, this is the central theme of this review. The possible mechanisms of the effects of these pharmacological agents are only discussed for treatments with demonstrated beneficial or harmful effects on behavioral recovery. An attempt is also made to indicate possible common mechanisms and the clinical potential of the various treatments; future directions for research are suggested.
最近，相当多的注意力都集中在开发促进脑损伤后功能恢复的药物治疗方法上。本文综述了两个领域的动物和人体实验，这两个领域在不久的将来似乎对促进恢复具有相当大的临床适用性：神经递质系统的药物操纵和神经节苷脂的给药。由于脑损伤后最重要的问题是恢复丧失的行为能力，这是本综述的核心主题。这些药物的作用机制仅针对那些已证明对行为恢复有有益或有害影响的治疗方法进行讨论。还试图指出各种治疗方法可能的共同机制和临床潜力；并提出了未来的研究方向。
