Xu X J, Wiesenfeld-Hallin Z
Department of Laboratory Medical Science and Technology, Karolinska Institute, Huddinge University Hospital, Sweden.
Neuroreport. 1994 Mar 21;5(7):750-2. doi: 10.1097/00001756-199403000-00003.
We examined the effects of intrathecal oxytocin over a wide dose range (10 ng to 10 micrograms) on the spinal nociceptive flexor reflex in decerebrate, spinalized, unanaesthetized rats. Oxytocin facilitated the flexor reflex at all doses. The duration, but not magnitude, of facilitation was dose-related. No reflex depression was observed with intrathecal oxytocin at any dose. It is suggested that activation of spinal oxytocin receptors excites the spinal cord and therefore intrathecal oxytocin is unlikely to be an analgesic agent.
我们研究了鞘内注射不同剂量范围（10纳克至10微克）的催产素对去大脑、脊髓横断、未麻醉大鼠脊髓伤害性屈肌反射的影响。所有剂量的催产素均能增强屈肌反射。增强的持续时间与剂量相关，但增强的幅度与剂量无关。任何剂量的鞘内注射催产素均未观察到反射抑制。提示脊髓催产素受体的激活会兴奋脊髓，因此鞘内注射催产素不太可能是一种镇痛剂。
