Sarfati M
Notre-Dame Hospital Research Center, University of Montréal, Canada.
Blood Cells. 1993;19(3):591-6; discussion 597-9.
Chronic lymphocytic leukemia (CLL) is classically defined by the proliferation and accumulation of monoclonal CD5 positive B cells "arrested" at an intermediate stage of differentiation. The CD23 antigen (the low affinity receptor for IgE (Fc epsilon RII) is a 45 kD membrane glycoprotein primarily expressed on surface IgM and IgD positive B cells. The aim of this paper is to establish the link between CD23 and CLL disease and to propose that the CD23 molecule is not simply a marker of CLL disease but may also be involved in the proliferation of the leukemic B cells.
慢性淋巴细胞白血病（CLL）的经典定义是，处于分化中间阶段的单克隆CD5阳性B细胞增殖并积聚。CD23抗原（IgE的低亲和力受体（FcεRII））是一种45kD的膜糖蛋白，主要表达于表面IgM和IgD阳性B细胞。本文旨在建立CD23与CLL疾病之间的联系，并提出CD23分子不仅是CLL疾病的一个标志物，还可能参与白血病B细胞的增殖。
