Aquilio E, Spagnoli R, Riggio D, Seri S
University La Sapienza, Roma, Italy.
J Trace Elem Electrolytes Health Dis. 1993 Dec;7(4):240-1.
The aim of the study was to examine the effects of oral zinc supplementation on liver ornithine transcarbamylase activity (OTC), a key enzyme in the urea cycle, in cirrhotic rats. OTC was studied in two groups of rats treated with carbon tetrachloride (CCl4): the first received zinc in the drinking water during the induction of cirrhosis; the second was the control group. Cirrhotic rats which received zinc supplementation showed an increase in liver OTC activity, positively correlated with serum and hepatic zinc content. The results suggest that zinc dietary supplementation may modify hepatic OTC activity and, therefore, plasma ammonia levels in cirrhotic rats.
本研究的目的是检测口服补充锌对肝硬化大鼠肝脏鸟氨酸转氨甲酰酶（OTC）活性的影响，OTC是尿素循环中的关键酶。在两组用四氯化碳（CCl4）处理的大鼠中研究OTC：第一组在肝硬化诱导期饮用含锌的水；第二组为对照组。接受补锌的肝硬化大鼠肝脏OTC活性增加，与血清和肝脏锌含量呈正相关。结果表明，饮食中补充锌可能会改变肝硬化大鼠肝脏OTC活性，进而影响血浆氨水平。
