Dickson I R, Gwilliam R, Arora M, Murphy S, Khaw K T, Phillips C, Lincoln P
Department of Biology and Biochemistry, Brunel University, Uxbridge, UK.
Bone Miner. 1994 Mar;24(3):181-8. doi: 10.1016/s0169-6009(08)80135-3.
alpha 2HS-glycoprotein (AHSG) is a plasma protein which becomes concentrated in the organic matrix of bone. The two most common alleles, AHSG1 and AHSG2, give rise to three common phenotypes. A recent report showed that a group of postmenopausal white North American women with different AHSG phenotypes differed significantly with respect to their oestrogen status. We have studied variations in bone mineral density, measured by DEXA, and levels of sex hormones and biochemical markers of bone metabolism in a group of 88 post-menopausal women unselected as to their health status. Lumbar vertebral and femoral neck bone mineral density (BMD), and the free oestradiol index were all significantly higher (P < 0.05) in women with the AHSG 2 phenotype. Values of these three parameters were lowest in the AHSG 1 phenotype and intermediate in the AHSG 2-1 phenotype. Because the differences in BMD between the AHSG 2 and 1 phenotypes represent at least a 40% difference in fracture risk, the AHSG phenotype may be of some clinical relevance as a risk factor for osteoporosis.
α2HS-糖蛋白（AHSG）是一种血浆蛋白，在骨的有机基质中会被浓缩。两种最常见的等位基因，AHSG1和AHSG2，产生三种常见的表型。最近的一份报告显示，一组具有不同AHSG表型的北美绝经后白人女性在雌激素状态方面存在显著差异。我们研究了一组88名未根据健康状况进行选择的绝经后女性中，通过双能X线吸收法（DEXA）测量的骨矿物质密度变化、性激素水平以及骨代谢的生化标志物。AHSG 2表型的女性腰椎和股骨颈骨矿物质密度（BMD）以及游离雌二醇指数均显著更高（P < 0.05）。这三个参数的值在AHSG 1表型中最低，在AHSG 2-1表型中处于中间水平。由于AHSG 2和1表型之间的BMD差异代表骨折风险至少有40%的差异，AHSG表型作为骨质疏松症的一个风险因素可能具有一定的临床相关性。
