AHSG gene polymorphisms are associated with bone mineral density in Caucasian nuclear families.

作者信息

Yang Yan-Jun, Wang Yan-Bo, Lei Shu-Feng, Long Ji-Rong, Shen Hui, Zhao Lan-Juan, Jiang De-Ke, Xiao Su-Mei, Chen Xiang-Ding, Chen Yuan, Deng Hong-Wen

机构信息

Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of the Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, PR China.

出版信息

Eur J Epidemiol. 2007;22(8):527-32. doi: 10.1007/s10654-007-9140-3. Epub 2007 Jun 8.

PURPOSE

To investigate the role of alpha2-HS glycoprotein (AHSG) gene on bone mineral density (BMD) variation.

METHODS

A total of 665 subjects from 157 Caucasian nuclear families were genotyped at the AHSG NlaIII, SacI sites. The association and linkage between the single SNP markers and haplotypes constructed by two markers in this gene and BMDs at the spine and hip were determined by using quantitative transmission disequilibrium test (QTDT).

RESULTS

Significant within-family associations were obtained for spine BMD at both of studied markers (P = 0.036 and 0.005 at the NlaIII and SacI sites, respectively). Significant (P = 0.008 at the NlaIII locus) (P = 0.004 at the SacI locus) total associations at spine BMD were detected. Haplotype analyses confirmed those within-family and total association.

CONCLUSIONS

These data suggest the polymorphisms in the AHSG gene may have effects on BMD variation in Caucasian population.