Sugimoto T, Nishino M, Tsunenari T, Kawakatsu M, Shimogaki K, Fujii Y, Negishi H, Tsutsumi M, Fukase M, Chihara K
Takatsuki General Hospital, Osaka, Japan.
Bone Miner. 1994 Mar;24(3):189-200. doi: 10.1016/s0169-6009(08)80136-5.
The present study was performed to measure appendicular bone mass of Japanese infants and children, and to assess the influence of age, sex and body size on bone mass during the period of bone growth. The bone mineral content (BMC) and bone width (BW) at the distal third of the radius were measured by single photon absorptiometry (SPA) in 229 healthy Japanese infants and children aged 0-12 years, and the BMC/BW ratio was calculated to give the bone mineral density (BMD). BMC and BW increased with age until 2 years, while BMD did not obviously change until 2 years. After 2 years of age, the overall effect of aging appeared more prominent in BMC and BMD than in BW. There were no significant differences in BMC, BW and BMD between males and females aged 0-12 years. Age, body height, and body weight were strongly correlated with three parameters of bone mass (BMC, BW, and BMD). Among the three parameters of bone mass, BMC showed the highest Pearson coefficient of correlation with age (r = 0.955), body height (r = 0.957) and body weight (r = 0.966), as compared with BW and BMD. The present cross-sectional study provides normative data of the appendicular bone mass in healthy Japanese children, which may serve as a standard for assessment of bone mineralization in Japanese infants and children with medical problems.
本研究旨在测量日本婴幼儿及儿童的附属骨骼质量，并评估骨骼生长期间年龄、性别和体型对骨骼质量的影响。采用单光子吸收法（SPA）测量了229名0至12岁健康日本婴幼儿及儿童桡骨远端三分之一处的骨矿物质含量（BMC）和骨宽度（BW），并计算BMC/BW比值以得出骨矿物质密度（BMD）。BMC和BW在2岁前随年龄增长而增加，而BMD在2岁前无明显变化。2岁以后，衰老对BMC和BMD的总体影响比BW更为显著。0至12岁的男性和女性在BMC、BW和BMD方面无显著差异。年龄、身高和体重与骨骼质量的三个参数（BMC、BW和BMD）密切相关。在骨骼质量的三个参数中，与BW和BMD相比，BMC与年龄（r = 0.955）、身高（r = 0.957）和体重（r = 0.966）的皮尔逊相关系数最高。本横断面研究提供了健康日本儿童附属骨骼质量的规范数据，可作为评估有健康问题的日本婴幼儿骨矿化情况的标准。
