Birnbaum B A, Bosniak M A, Krinsky G A, Cheng D, Waisman J, Ambrosino M M
Department of Radiology, New York University Medical Center, NY 10016.
Abdom Imaging. 1994 May-Jun;19(3):262-6. doi: 10.1007/BF00203523.
The contrast-enhanced preoperative computed tomographic (CT) scans and microscopic slides of 94 patients with 100 surgically resected renal cell carcinomas (RCCs) were retrospectively and independently reviewed in order to correlate the CT imaging findings of RCC with nuclear grading. As nuclear grade increased, RCCs were more likely to be of higher stage and greater size at presentation, and appeared more heterogeneous and less marginated. Of the features analyzed, tumor margination most closely correlated with nuclear grade. Overlap in the CT appearance of individual tumors limited the potential of CT to differentiate RCCs of varying grade. Small, well-marginated, homogeneous tumors, however, were either grade I or II, and were distinguishable from the more aggressive grade III lesions, which generally displayed irregular margins and greater inhomogeneity.
对94例接受手术切除的100个肾细胞癌（RCC）患者的术前增强计算机断层扫描（CT）图像和显微切片进行了回顾性独立分析，以关联RCC的CT影像学表现与核分级。随着核分级增加，RCC在初诊时更可能处于更高分期、更大体积，且表现出更多的异质性和边界欠清晰。在所分析的特征中，肿瘤边界与核分级的相关性最为密切。个体肿瘤的CT表现存在重叠，限制了CT区分不同分级RCC的能力。然而，边界清晰、均匀的小肿瘤为I级或II级，可与更具侵袭性的III级病变区分，III级病变通常边界不规则且异质性更强。
