Melikian A A, Prahalad A K, Secker-Walker R H
American Health Foundation, Valhalla, New York 10595.
Cancer Epidemiol Biomarkers Prev. 1994 Apr-May;3(3):239-44.
Urinary trans,trans-muconic acid, a ring-opened metabolite of benzene, was quantified in pregnant and nonpregnant smokers. The results of this study were compared with those reported previously in male smokers. The data clearly demonstrate that smoking increases the levels of trans,trans-muconic acid in urine. The mean levels of trans,trans-muconic acid in the urine of groups of male, female, and pregnant smokers were 3.6-, 4.8-, and 4.5-fold higher than those in the nonsmoking counterparts. Mean concentrations of trans,trans-muconic acid in groups of 42 men and 53 nonpregnant women were 0.22 +/- 0.03 (SE) and 0.24 +/- 0.02 mg/g creatinine, or 0.13 +/- 0.6 and 0.13 +/- 0.07 mg/mg cotinine, respectively. These data reveal that urinary trans,trans-muconic acid levels in female smokers are nearly the same as in male smokers. Mean levels of trans,trans-muconic acid in the urine of groups of 63 pregnant and 53 nonpregnant women were 0.27 +/- 0.04 and 0.24 +/- 0.02 mg/g creatinine, or 0.24 +/- 0.06 and 0.13 +/- 0.07 mg/mg cotinine, respectively. Mean concentrations of urinary cotinine in pregnant women were significantly lower than in the group of nonpregnant women (1.13 +/- 0.12 versus 1.82 +/- 0.14 mg/g creatinine). When levels of trans,trans-muconic acid were normalized against urinary cotinine, the mean concentration in urine of pregnant smokers was almost 2-fold greater than that in nonpregnant smokers. This could be due to an increased metabolism of benzene to urinary trans,trans-muconic acid during pregnancy.(ABSTRACT TRUNCATED AT 250 WORDS)
对怀孕和未怀孕的吸烟者尿液中的反式，反式-粘康酸（苯的一种开环代谢物）进行了定量分析。本研究结果与之前报道的男性吸烟者的结果进行了比较。数据清楚地表明，吸烟会增加尿液中反式，反式-粘康酸的水平。男性、女性和怀孕吸烟者尿液中反式，反式-粘康酸的平均水平分别比不吸烟的对应者高3.6倍、4.8倍和4.5倍。42名男性和53名未怀孕女性组中反式，反式-粘康酸的平均浓度分别为0.22±0.03（标准误）和0.24±0.02毫克/克肌酐，或分别为0.13±0.06和0.13±0.07毫克/毫克可替宁。这些数据表明，女性吸烟者尿液中反式，反式-粘康酸水平与男性吸烟者几乎相同。63名怀孕女性和53名未怀孕女性组尿液中反式，反式-粘康酸的平均水平分别为0.27±0.04和0.24±0.02毫克/克肌酐，或分别为0.24±0.06和0.13±0.07毫克/毫克可替宁。孕妇尿液中可替宁的平均浓度显著低于未怀孕女性组（1.13±0.12对1.82±0.14毫克/克肌酐）。当反式，反式-粘康酸水平以尿液可替宁进行标准化时，怀孕吸烟者尿液中的平均浓度几乎是非怀孕吸烟者的2倍。这可能是由于怀孕期间苯代谢为尿液中反式，反式-粘康酸的代谢增加所致。（摘要截选至250字）
