巨噬细胞迁移抑制因子蛋白不是谷胱甘肽转移酶同源物。
MIF proteins are not glutathione transferase homologs.
作者信息
Pearson W R
机构信息
Department of Biochemistry, University of Virginia, Charlottesville 22908.
出版信息
Protein Sci. 1994 Mar;3(3):525-7. doi: 10.1002/pro.5560030318.
Although macrophage migration inhibitory factor (MIF) proteins conjugate glutathione, sequence analysis does not support their homology to other glutathione transferases. Glutathione transferases are not detected with MIF proteins in searches of protein sequence databases, and MIF proteins do not share significant sequence similarity with glutathione transferases. Homology cannot be demonstrated by multiple sequence alignment or evolutionary tree construction; such methods assume that the proteins being analyzed are homologous.
尽管巨噬细胞迁移抑制因子（MIF）蛋白可与谷胱甘肽结合，但序列分析并不支持它们与其他谷胱甘肽转移酶具有同源性。在蛋白质序列数据库搜索中，未发现MIF蛋白具有谷胱甘肽转移酶活性，且MIF蛋白与谷胱甘肽转移酶不存在显著的序列相似性。通过多序列比对或进化树构建无法证明其同源性；此类方法假定所分析的蛋白质是同源的。
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