人类θ类谷胱甘肽S-转移酶和D-多巴色素互变异构酶基因复合体的结构与组织
Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex.
作者信息
Coggan M, Whitbread L, Whittington A, Board P
机构信息
Molecular Genetics Group, John Curtin School of Medical Research, Australian National University, P.O. Box 334, Canberra, ACT 2601, Australia.
出版信息
Biochem J. 1998 Sep 15;334 ( Pt 3)(Pt 3):617-23. doi: 10.1042/bj3340617.
Abstract
The structure and organization of the human Theta-class glutathione S-transferase (GST) genes have been determined. GSTT1 and GSTT2 are separated by approx. 50 kb. They have a similar structure, being composed of five exons with identical exon/intron boundaries. GSTT1 is 8.1 kb in length, while GSTT2 is only 3.7 kb. The GSTT2 gene lies head-to-head with a gene encoding d-dopachrome tautomerase (DDCT), which extends over 8.5 kb and contains four exons. The sequence between GSTT2 and DDCT may contain a bidirectional promoter. The GSTT2 and DDCT genes have been duplicated in an inverted repeat. Sequence analysis of the duplicated GSTT2 gene has identified an exon 2/intron 2 splice site abnormality and a premature translation stop signal at codon 196. These changes suggest that the duplicate gene is a pseudogene, and it has been named GSTT2P.
摘要
人类θ类谷胱甘肽S-转移酶（GST）基因的结构和组织已被确定。GSTT1和GSTT2相隔约50 kb。它们具有相似的结构，由五个外显子组成，外显子/内含子边界相同。GSTT1长度为8.1 kb，而GSTT2仅为3.7 kb。GSTT2基因与一个编码d-多巴色素互变异构酶（DDCT）的基因头对头排列，该基因长度超过8.5 kb，包含四个外显子。GSTT2和DDCT之间的序列可能包含一个双向启动子。GSTT2和DDCT基因以反向重复的形式发生了复制。对复制的GSTT2基因的序列分析发现了一个外显子2/内含子2剪接位点异常以及一个位于第196密码子处的过早翻译终止信号。这些变化表明该复制基因是一个假基因，它被命名为GSTT2P。
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