Landeau J M, Pellat B, Hornebeck W
Biochemistry Department, Faculty of Dental Surgery, University René Descartes Paris V, Montrouge, France.
Cell Biol Int. 1994 Feb;18(2):111-7. doi: 10.1006/cbir.1994.1050.
Elastin-derived peptides were previously shown to influence human skin fibroblasts (HSF) chemotaxis and proliferation (Ghuysen et al., 1992). We report here that culturing HSF on kappa-elastin (kappa E) but not onto fibronectin (FN) enhanced the secretion of latent elastinolytic activity. The proteinase involved was identified as the 72 kDa gelatinase A. Moreover, HSF-kappa E as well as HSF-FN interactions modulated the secretions of Il1 induced expressions of elastinolytic activities.
