Scott G K, Tse C A
School of Biological Sciences, University of Auckland, New Zealand.
Cell Biol Int. 1994 Feb;18(2):89-93. doi: 10.1006/cbir.1994.1047.
Inhibition of a cell-surface proteinase can inhibit the growth of many normal human cell types in culture. Some tumour cells are also sensitive to proteinase inhibitors, but others are resistant, and continue to grow in the presence of these inhibitors. Here we describe two human tumour cell lines which convert from the sensitive to the resistant state. In one case, the conversion occurs during routine passaging, but, in the other, it is determined by growth conditions, and is reversible.
抑制一种细胞表面蛋白酶能够抑制培养中的多种正常人类细胞类型的生长。一些肿瘤细胞对蛋白酶抑制剂也敏感，但其他肿瘤细胞则具有抗性，并且在这些抑制剂存在的情况下仍能继续生长。在此，我们描述了两种从敏感状态转变为抗性状态的人类肿瘤细胞系。在一种情况下，这种转变发生在常规传代过程中，但在另一种情况下，它由生长条件决定，并且是可逆的。
