Inhibition of an endogenous growth-related proteinase enhances the recovery of a negative growth regulator from cultured human cells.
作者信息
Manilal S, Scott G K, Tse C A
机构信息
Department of Biochemistry, University of Auckland, New Zealand.
出版信息
Cell Biol Int. 1993 Mar;17(3):317-23. doi: 10.1006/cbir.1993.1067.
PMID:8513299
Abstract
The possibility that a growth-related proteinase may act by degrading a negative growth regulatory protein has been investigated. Proteinase inhibitors which inhibit the enzyme also enhance the accumulation of the growth regulator by human fibroblasts. The negative growth regulator shows a similar specificity of inhibition of cellular growth to inhibitors of the growth-related proteinase.
摘要
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