Apkarian P, Bour L, Barth P G
Department of Physiology I, Faculty of Medicine, Erasmus University, Rotterdam, Netherlands.
Eur J Neurosci. 1994 Mar 1;6(3):501-7. doi: 10.1111/j.1460-9568.1994.tb00293.x.
In mammals with binocular vision, projections of retinal axons to primary retino-recipient nuclei establish a strict visuotopic and eye-segregated arrangement. Normal primate visual pathway organization is characterized by orderly hemiretina separation in which nasal-retinal axons cross at the optic chiasm and project to primary contralateral subcortical and cortical structures while temporal-retinal fibres project ipsilaterally to corresponding visual structures. We report here, in two unrelated children, an unusual visual pathway malformation in which nasal-retinal cortical projections, unable to decussate due to the inborn absence of an optic chiasm, erroneously route ipsilaterally to visual projection targets. We have termed this newly documented achiasmatic condition the non-decussating retinal-fugal fibre syndrome (Apkarian et al., Invest. Ophthalmol. Vis. Sci., 34, Suppl., 711, 1993).
在具有双眼视觉的哺乳动物中，视网膜轴突向主要视网膜接受核的投射建立了严格的视拓扑和眼部分离排列。正常灵长类动物视觉通路组织的特征是半视网膜有序分离，其中鼻侧视网膜轴突在视交叉处交叉，并投射到对侧的初级皮质下和皮质结构，而颞侧视网膜纤维同侧投射到相应的视觉结构。我们在此报告了两名无亲缘关系的儿童，他们存在一种不寻常的视觉通路畸形，其中鼻侧视网膜皮质投射由于先天性缺乏视交叉而无法交叉，错误地同侧路由到视觉投射目标。我们将这种新记录的无交叉症情况称为非交叉视网膜逃逸纤维综合征（Apkarian等人，《Invest.Ophthalmol.Vis.Sci.》，34，增刊，711，1993）。
