Gault L M, Lin C W, LaManna J C, Lust W D
Laboratory of Experimental Neurological Surgery, University Hospitals of Cleveland, OH.
Brain Res. 1994 Mar 28;641(1):176-80. doi: 10.1016/0006-8993(94)91835-x.
The spatial and temporal distribution of cerebral metabolites and pHi were examined in the cortex during spreading depression. Acidification and marked depression in the energy status of the tissue was evident at the wavefront of spreading depression. In its aftermath, the residual activation of glycolysis and accumulation of cGMP persisted for minutes after a relatively rapid restoration of high-energy phosphates and pHi.
在扩散性抑制期间，对大脑皮层中脑代谢物和细胞内pH值的时空分布进行了研究。在扩散性抑制的波前，组织的酸化和能量状态的显著降低是明显的。在其后果中，糖酵解的残余激活和cGMP的积累在高能磷酸盐和细胞内pH值相对快速恢复后持续了几分钟。
