Welch K M, Barkley G L, Ramadan N M, D'Andrea G
William T. Gossett Chairs Department of Neurology, Henry Ford Hospital, Detroit, MI 48202.
Pathol Biol (Paris). 1992 Apr;40(4):349-54.
The authors propose that patients who suffer from migraine with aura have a susceptibility to spontaneous neuronal discharges and subsequent spreading depression. This is based upon a state of central neuronal excitability involving the excitatory neurotransmitter glutamate, in combination with supersensitivity of the N-méthyl-D-aspartate (NMDA) receptor. This hypersusceptibility is supported by increased turnover of high-energy phosphates, low intracellular Mg2+ and large amplitude depolarizing waves on magnetoencephalography (MEG).
作者提出，患有先兆偏头痛的患者易发生自发性神经元放电及随后的扩散性抑制。这是基于一种涉及兴奋性神经递质谷氨酸的中枢神经元兴奋性状态，以及N-甲基-D-天冬氨酸（NMDA）受体的超敏反应。高能磷酸盐周转增加、细胞内镁离子浓度低以及脑磁图（MEG）上的大幅度去极化波支持了这种高敏感性。
