Perrin P, Burg C, Vavasseur F, Galmiche J P, Bornet F, Meflah K
Laboratoire de Biochimie Médicale, INSERM-CJF 90.11, Institut de Biologie, Nantes, France.
C R Acad Sci III. 1993 Jun;316(6):611-4.
Two therapeutic assays associating sodium butyrate (NaB) and interleukin-2 (IL-2) were applied on rats after intraperitoneal (i.p.) injection of colon carcinoma cells. The first assay began at day 1 after cell injection, and the second one at day 10 after injection, i.e. when carcinomatosis was established. IL-2 was given i.p. three times per day and NaB one time per day, for five and seven days respectively. The survival median of IL-2 treated rats significantly increased versus those of untreated ones, and was much higher with NaB in supplement. Moreover, using this associative treatment, we observed some cases of complete curacy, even in rats bearing established carcinomatosis.
在腹腔内注射结肠癌细胞后，对大鼠应用了两种将丁酸钠（NaB）与白细胞介素-2（IL-2）联合使用的治疗试验。第一个试验在细胞注射后第1天开始，第二个试验在注射后第10天开始，即当癌转移形成时。IL-2每天腹腔注射3次，NaB每天注射1次，分别持续5天和7天。与未治疗的大鼠相比，接受IL-2治疗的大鼠的中位生存期显著延长，补充NaB后生存期更高。此外，使用这种联合治疗，我们观察到一些完全治愈的病例，即使是在患有已形成癌转移的大鼠中。
