伪狂犬病病毒相关生长因子对叙利亚仓鼠胚胎细胞的形态学转化
Morphological transformation of Syrian hamster embryo cells by pseudorabies virus related growth factor.
作者信息
Dusinskaá M, Lesko J, Golais F, Slamenová D
机构信息
Department of Mutagenesis and Chemical Carcinogenesis, Slovak Academy of Sciences, Bratislava.
出版信息
Cancer Lett. 1994 May 16;79(2):125-9. doi: 10.1016/0304-3835(94)90250-x.
Syrian hamster embryo (SHE) clonal morphological transformation assay has been used for the in vitro testing of transforming activity of Pseudorabies virus (PRV) related growth factor (PRGF). It was found that PRGF induces morphologically transformed colonies of SHE cells in the wide titer scale (in the range 1 x 10(7) to 1 x 10(13) U/ml). The concentrations of PRGF which induced the transforming phenotype of SHE cells in the colonies did not cause significant cytotoxic effect.
叙利亚仓鼠胚胎（SHE）克隆形态转化试验已用于体外检测伪狂犬病病毒（PRV）相关生长因子（PRGF）的转化活性。结果发现，PRGF在较宽的效价范围内（1×10⁷至1×10¹³ U/ml）可诱导SHE细胞形成形态转化的集落。在集落中诱导SHE细胞出现转化表型的PRGF浓度不会引起明显的细胞毒性作用。
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