Demethylation of O6-methylguanine in DNA by O6-methylguanine-DNA methyltransferase: synthesis and characterization of O6,9-dimethylguanine coordinated with cis-platin at the N7-position.
作者信息
Terashima I, Yamagata Y, Yamagami N, Kohda K
机构信息
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1994 Apr;42(4):903-6. doi: 10.1248/cpb.42.903.
PMID:8020126
Abstract
In order to investigate the chemical characteristics of O6-methylguanines, the substrate of O6-methylguanine-DNA methyltransferase, cis[PtCl(NH3)2(O6,9-dimethylguanine-7)]NO3, a 1:1 complex of cis-platin with O6,9-dimethylguanine, was synthesized and its demethylation rate, pKa, X-ray structure and cytotoxicity were determined.
摘要
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