O6,9-二甲基鸟嘌呤与顺铂复合物的化学特性及O6-苄基鸟嘌呤的脱苄基速率
Chemical characteristics of complexes of O6,9-dimethylguanine with cis-platin and debenzylation rates of O6-benzylguanines.
作者信息
Terashima I, Koyama K, Kohda K
机构信息
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
出版信息
Nucleic Acids Symp Ser. 1993(29):23-4.
PMID:8247776
Abstract
Complexes of O6,9-dimethylguanine with cisplatin were synthesized and their chemical characteristics were studied in relation to the function of the repair enzyme, O6-alkylguanine-DNA alkyltransferase (AGAT). In addition, dealkylation rates of O6-benzylguanine derivatives, that are though to be better substrates for AGAT, were determined by the thiophenol-Et3N system.
摘要
合成了O6,9-二甲基鸟嘌呤与顺铂的复合物，并结合修复酶O6-烷基鸟嘌呤-DNA烷基转移酶（AGAT）的功能研究了它们的化学特性。此外，通过硫酚-Et3N体系测定了被认为是AGAT更好底物的O6-苄基鸟嘌呤衍生物的脱烷基化速率。
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