氨基酸与肽。二十一。层粘连蛋白相关肽类似物，包括聚乙二醇杂化物及其对实验性转移的抑制作用。

Amino acids and peptides. XXI. Laminin-related peptide analogs including poly(ethylene glycol) hybrids and their inhibitory effect on experimental metastasis.

作者信息

Kawasaki K, Murakami T, Namikawa M, Mizuta T, Iwai Y, Yamashiro Y, Hama T, Yamamoto S, Mayumi T

机构信息

Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1994 Apr;42(4):917-21. doi: 10.1248/cpb.42.917.

DOI:10.1248/cpb.42.917

PMID:8020127

Abstract

Laminin-related peptides, Tyr-Ile-Gly-Ser-Arg analogs, were prepared and their inhibitory effects on experimental metastasis were examined. Of the amino acids in the Tyr-Ile-Gly-Ser-Arg sequence, L-Arg was very important and Ile was not essential for the inhibitory effect. To obtain a potent inhibitor of metastasis, hybrids of Tyr-Ile-Gly-Ser-Arg-Gly and 2 types of poly(ethylene glycol) were prepared. The inhibitory effects of the hybrids were more potent than that of Tyr-Ile-Gly-Ser-Arg-Gly.

摘要

制备了层粘连蛋白相关肽，即酪氨酸 - 异亮氨酸 - 甘氨酸 - 丝氨酸 - 精氨酸类似物，并检测了它们对实验性转移的抑制作用。在酪氨酸 - 异亮氨酸 - 甘氨酸 - 丝氨酸 - 精氨酸序列中的氨基酸中，L - 精氨酸非常重要，而异亮氨酸对抑制作用并非必不可少。为了获得一种有效的转移抑制剂，制备了酪氨酸 - 异亮氨酸 - 甘氨酸 - 丝氨酸 - 精氨酸 - 甘氨酸与两种聚乙二醇的杂化物。这些杂化物的抑制作用比酪氨酸 - 异亮氨酸 - 甘氨酸 - 丝氨酸 - 精氨酸 - 甘氨酸更强。