氨基酸与肽。XXV. 纤连蛋白相关肽聚乙二醇杂化物的制备及其对实验性转移的抑制作用。

Amino acids and peptides. XXV. Preparation of fibronectin-related peptide poly(ethylene glycol) hybrids and their inhibitory effect on experimental metastasis.

作者信息

Kawasaki K, Namikawa M, Yamashiro Y, Iwai Y, Hama T, Tsutsumi Y, Yamamoto S, Nakagawa S, Mayumi T

机构信息

Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1995 Dec;43(12):2133-8. doi: 10.1248/cpb.43.2133.

DOI:10.1248/cpb.43.2133

PMID:8582015

Abstract

Hybrids of fibronectin-related peptides [Arg-Gly-Asp (RGD), Arg-Gly-Asp-Ser (RGDS)] and poly(ethylene glycol) (PEG) were prepared and their inhibitory effects on experimental metastasis in mice were examined. The inhibitory effect of RGD was markedly potentiated by hybrid formation with poly(ethylene glycol) #6000. As to inhibitory effect, RGD was more potent than RGDS and RGD PEG hybrids were superior to RGDS PEG hybrids. Hybrid formation with PEG #6000 was more effective than that with PEG #4000.

摘要

制备了纤连蛋白相关肽[精氨酸-甘氨酸-天冬氨酸（RGD）、精氨酸-甘氨酸-天冬氨酸-丝氨酸（RGDS）]与聚乙二醇（PEG）的杂化物，并检测了它们对小鼠实验性转移的抑制作用。通过与聚乙二醇#6000形成杂化物，RGD的抑制作用显著增强。就抑制作用而言，RGD比RGDS更有效，且RGD-PEG杂化物优于RGDS-PEG杂化物。与聚乙二醇#6000形成杂化物比与聚乙二醇#4000更有效。