Filipo R, Barbara M
Department of Otolaryngology, University La Sapienza, Rome, Italy.
Ear Nose Throat J. 1994 Apr;73(4):254-7.
Menière's disease (MD) is considered a complex otologic disorder characterized by exacerbation and remission periods which often make its natural course unpredictable. Several studies in the past have analyzed the evolutionary course of MD through comparison between patients under medical treatment and those surgically treated. The present paper aimed to study the evolution of MD in a group of patients who were selected for endolymphatic sac surgery on the basis of a fluctuating stage and uncontrollable recurrent vertigo; some of them, however, did not undergo surgery for different reasons and were used as control for MD at a homogenous stage. Vertigo and tinnitus were improved by surgery in a significant number of patients in comparison with the non-surgical group. Hearing function, which improved few months after surgery in some patients, was found to deteriorate in the long run, in surgical and non-surgical groups. Sac surgery yielded significantly better results for two out of three Meniere's symptoms, i.e. vertigo and tinnitus, and can be considered to play a significant role in the therapy of MD at the fluctuating stage.
梅尼埃病（MD）被认为是一种复杂的耳科疾病，其特征为病情有加重期和缓解期，这常常使其自然病程难以预测。过去的几项研究通过比较接受药物治疗的患者和接受手术治疗的患者，分析了MD的演变过程。本文旨在研究一组因处于波动期且反复眩晕无法控制而被选进行内淋巴囊手术的患者中MD的演变情况；然而，其中一些患者因不同原因未接受手术，并被用作同一阶段MD的对照。与非手术组相比，大量接受手术的患者的眩晕和耳鸣症状得到改善。在手术组和非手术组中，部分患者术后几个月听力功能有所改善，但从长远来看听力功能会恶化。内淋巴囊手术对梅尼埃病的三个症状中的两个，即眩晕和耳鸣，产生了明显更好的效果，并且可以认为在内淋巴囊波动期MD的治疗中发挥了重要作用。
