Evaluation of the radiographic efficacy of iomeprol.

Iomeprol, a new nonionic contrast medium, was administered at concentrations of 300 mgI/ml, 350 mgI/ml, and 400 mgI/ml to 1939 Japanese patients. The radiographic efficacy, the incidence of heat sensation and the incidence of pain were evaluated. The radiographic efficacy was rated as excellent in 80.6% and good in 17.5% of 1017 cases of conventional arteriography, excellent in 75.6% and good in 22.2% of 267 cases of IADSA or IVDSA, excellent in 78.3% and good in 19.6% of 384 cases of intravenous urography and excellent in 68.6% and good in 28.8% of 271 cases of CT enhancement. There was no statistical difference in radiographic efficacy between the sites of arteriography. Heat sensation was mild or moderate in 43.4% and severe in 0.2% of cases requiring intra-arterial injection, and mild or moderate in 50.7% of cases requiring intravenous injection. There were no cases of severe heat sensation following intravenous injection. The incidence of pain was low (mild 4.2%, moderate 0.7% and severe 0.1%) with intra-arterial injections. It is concluded that iomeprol is an excellent radiographic contrast medium for intravenous urography, CT enhancement and various forms of angiography.