Storto M L, Ciccotosto C, Patea R L, Spinazzi A, Bonomo L
Radiology Department, University of Chieti, SS Annunziata Hospital, Italy.
Eur J Radiol. 1994 May;18 Suppl 1:S83-7. doi: 10.1016/0720-048x(94)90099-x.
Spiral computed tomography (CT) allows very satisfactory temporal resolution for the detection and analysis of changes in contrast medium density, so that volumes of contrast material smaller than those recommended for conventional CT can be used. The present double-blind, parallel group study was designed to compare image quality and diagnostic efficacy obtained with two different iodine strengths (200 and 300 mgI/ml) and two different flow rates (2 and 3 ml/s) of a fixed volume (70 ml) of iomeprol in adult consenting patients requiring spiral CT of the mediastinum. Imaging was performed during suspended respiration and, a 15-s delay to scan. Spiral CT was initiated 1 cm above the aortic arch and continued inferiorly for 24 cm in all patients. Two independent readers blindly graded image quality, opacification of the superior vena cava, thoracic aorta and pulmonary arteries, and overall diagnostic quality of the CT examination. CT density measurements were performed over the level of the aortic arch, left and right pulmonary arteries, left atrium, and descending aorta. Opacification of the mediastinal vessels was better in the patients injected at 3 ml/s flow rate and was independent of the iodine strength used, except in the case of the thoracic aorta, which was better opacified by injecting iomeprol 300 mgI/ml at 3 ml/s. The highest diagnostic efficacy of the spiral CT examination was obtained with iomeprol 300 mgI/ml at 3 ml/s infusion rate, which seems to represent the administration scheme of choice.
螺旋计算机断层扫描（CT）对于检测和分析造影剂密度变化具有非常令人满意的时间分辨率，因此可以使用比传统CT推荐剂量更小的造影剂体积。本双盲、平行组研究旨在比较在需要进行纵隔螺旋CT的成年自愿患者中，使用两种不同碘浓度（200和300 mgI/ml）以及两种不同流速（2和3 ml/s）的固定体积（70 ml）碘美普尔所获得的图像质量和诊断效果。成像在屏气期间进行，并延迟15秒进行扫描。所有患者均从主动脉弓上方1 cm处开始进行螺旋CT扫描，并向下持续扫描24 cm。两名独立的阅片者对图像质量、上腔静脉、胸主动脉和肺动脉的显影情况以及CT检查的整体诊断质量进行盲法分级。在主动脉弓、左右肺动脉、左心房和降主动脉水平进行CT密度测量。流速为3 ml/s的患者纵隔血管显影更好，且与所用碘浓度无关，但胸主动脉除外，流速为3 ml/s时注射300 mgI/ml碘美普尔显影更佳。以3 ml/s的输注速率使用300 mgI/ml碘美普尔时，螺旋CT检查获得了最高的诊断效能，这似乎是首选的给药方案。
