Whitfield K E
Exp Aging Res. 1994 Apr-Jun;20(2):135-43. doi: 10.1080/03610739408253959.
There is great interest in the interindividual variability in aged populations. Knowledge of the etiology of these individual differences may lead to a more comprehensive understanding of aging. The purpose of this article is to discuss the use of quantitative genetic (or behavioral genetic) methodology to identify sources of individual variation in later life. These methods can provide insights into the proportion of environmental and genetic influences on behavior. Some of the basic procedures used in quantitative genetic analyses and their rationales are provided. In addition, the use of structural equation modeling to model genetic and environmental effects is discussed. Lastly, some of the special issues involved in quantitative genetic research on aged populations are discussed.
老年人群个体间的变异性备受关注。了解这些个体差异的病因可能会使我们对衰老有更全面的认识。本文旨在探讨使用数量遗传学（或行为遗传学）方法来确定晚年个体差异的来源。这些方法可以深入了解环境和遗传因素对行为的影响比例。文中提供了数量遗传学分析中使用的一些基本程序及其原理。此外，还讨论了使用结构方程模型来模拟遗传和环境效应。最后，讨论了老年人群数量遗传学研究中涉及的一些特殊问题。
