Yamamoto Y, Sezai S, Sakurabayashi S, Hirano M, Kamisaka K, Oka H
Division of Gastroenterology, Tokyo Metropolitan Police Hospital, Japan.
J Int Med Res. 1994 Mar-Apr;22(2):95-9. doi: 10.1177/030006059402200205.
Hepatic reticuloendothelial function may be diminished in patients with primary biliary cirrhosis. Endotoxin concentrations in peripheral blood and in the superior mesenteric vein were measured, by the beta-glucan sensitive, factor-free, endotoxin-specific limulus assay, in patients with primary biliary cirrhosis and liver cirrhosis (non-PBC cirrhosis). Endotoxaemia was detected in the peripheral blood of seven out of nine patients (78%) with asymptomatic primary biliary cirrhosis, but in only two out of thirteen patients (15%) with non-PBC cirrhosis. The endotoxin level was significantly higher in the earlier stages of primary biliary cirrhosis than in the later stages (P < 0.05). The endotoxin level in superior mesenteric vein blood was significantly lower in patients with primary biliary cirrhosis than in patients with non-PBC cirrhosis. Peripheral endotoxaemia in patients with primary biliary cirrhosis may be due to the diminished capacity of the hepatic reticuloendothelial system, for phagocytosis of endotoxin.
原发性胆汁性肝硬化患者的肝网状内皮系统功能可能会减退。采用β-葡聚糖敏感、无因子、内毒素特异性鲎试剂法，对原发性胆汁性肝硬化患者和肝硬化（非原发性胆汁性肝硬化）患者的外周血及肠系膜上静脉内毒素浓度进行了测定。在9例无症状原发性胆汁性肝硬化患者中，有7例（78%）外周血检测到内毒素血症，但在13例非原发性胆汁性肝硬化患者中，只有2例（15%）检测到内毒素血症。原发性胆汁性肝硬化早期的内毒素水平显著高于晚期（P<0.05）。原发性胆汁性肝硬化患者肠系膜上静脉血中的内毒素水平显著低于非原发性胆汁性肝硬化患者。原发性胆汁性肝硬化患者的外周血内毒素血症可能是由于肝网状内皮系统对内毒素的吞噬能力下降所致。
