Swain Mark G
University of Calgary, Liver Unit, Health Sciences Centre, Alberta.
Can J Gastroenterol. 2006 Mar;20(3):181-8. doi: 10.1155/2006/624832.
Fatigue is the most commonly encountered symptom in patients with liver disease, and it has a significant impact on their quality of life. However, although some progress has been made with regard to the understanding of the processes which may generate fatigue in general, the underlying cause(s) of liver disease-associated fatigue remain incompletely understood. The present review describes recent advances which have been made in our ability to measure fatigue in patients with liver disease in the clinical setting, as well as in our understanding of potential pathways which are likely important in the pathogenesis of fatigue associated with liver disease. Specifically, experimental findings suggest that fatigue associated with liver disease likely occurs as a result of changes in neurotransmission within the brain. In conclusion, a reasonable approach to help guide in the management of the fatigued patient with liver disease is presented.
疲劳是肝病患者最常见的症状，对他们的生活质量有重大影响。然而，尽管在总体上对可能产生疲劳的过程的理解取得了一些进展，但与肝病相关的疲劳的潜在原因仍未完全明了。本综述描述了在临床环境中测量肝病患者疲劳的能力方面取得的最新进展，以及我们对在与肝病相关的疲劳发病机制中可能重要的潜在途径的理解。具体而言，实验结果表明，与肝病相关的疲劳可能是由于大脑内神经传递的变化所致。总之，本文提出了一种有助于指导肝病疲劳患者管理的合理方法。
