刘易斯血型表型、分泌状态与乳糜泻
Lewis phenotype, secretor status, and coeliac disease.
作者信息
Dickey W, Wylie J D, Collins J S, Porter K G, Watson R G, McLoughlin J C
机构信息
Department of Medicine, Queen's University of Belfast.
出版信息
Gut. 1994 Jun;35(6):769-70. doi: 10.1136/gut.35.6.769.
Patients who cannot secrete ABO and Lewis blood group antigens into body fluids, an ability controlled by a single gene on chromosome 19, are known to be at increased risk of certain autoimmune diseases associated with human leucocyte antigen (HLA) markers. This study investigated the possibility of an association with coeliac disease using red cell Lewis (Le) blood group phenotype to infer secretor status. Among 73 patients with coeliac disease who had Le a or b antigen, 48% were non-secretors (Le a + b-) compared with 27% of 137 blood donors (p = 0.004: odds ratio 2.49, 95% confidence intervals 1.37 to 4.51) and 26% of 62 medical and nursing staff controls (p = 0.014: odds ratio 2.65, 95% confidence intervals 1.27 to 5.50). Clinical characteristics did not differ between secretors and non-secretors with coeliac disease. Thus, the non-secretor state is significantly associated with coeliac disease, suggesting that genes on chromosome 19 may directly or indirectly participate in conferring susceptibility.
无法将ABO和Lewis血型抗原分泌到体液中的患者，其这种能力由19号染色体上的单个基因控制，已知这些患者患某些与人类白细胞抗原（HLA）标记相关的自身免疫性疾病的风险会增加。本研究利用红细胞Lewis（Le）血型表型来推断分泌状态，调查了其与乳糜泻之间关联的可能性。在73例具有Le a或b抗原的乳糜泻患者中，48%为非分泌者（Le a + b-），相比之下，137名献血者中有27%为非分泌者（p = 0.004：比值比2.49，95%置信区间1.37至4.51），62名医护人员对照中有26%为非分泌者（p = 0.014：比值比2.65，95%置信区间1.27至5.50）。乳糜泻患者中分泌者和非分泌者的临床特征并无差异。因此，非分泌状态与乳糜泻显著相关，这表明19号染色体上的基因可能直接或间接参与了易感性的赋予。
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