麸质敏感性肠病中的免疫球蛋白同种异型标志物。
Immunoglobulin allotype markers in gluten-sensitive enteropathy.
作者信息
Kagnoff M F, Weiss J B, Brown R J, Lee T, Schanfield M S
出版信息
Lancet. 1983 Apr 30;1(8331):952-3. doi: 10.1016/s0140-6736(83)92080-9.
Immunoglobulin allotype markers and HLA-A, HLA-B, and HLA-DR locus antigens were determined in 30 White patients with gluten-sensitive enteropathy and 30 controls matched for age, ethnic background, and geographic origin. All patients lacking HLA-B8 and HLA-DR3 had the IgG (Gm) immunoglobulin heavy-chain phenotype Gm (f;n;b). Thus, in addition to major histocompatibility locus genes, it appears that genes linked to the immunoglobulin heavy-chain allotype locus on chromosome 14 may influence susceptibility in gluten-sensitive enteropathy.
在30例患有麸质敏感性肠病的白人患者以及30名在年龄、种族背景和地理来源上相匹配的对照者中，检测了免疫球蛋白同种异型标记以及HLA - A、HLA - B和HLA - DR位点抗原。所有缺乏HLA - B8和HLA - DR3的患者都具有IgG（Gm）免疫球蛋白重链表型Gm（f；n；b）。因此，除了主要组织相容性位点基因外，位于14号染色体上与免疫球蛋白重链同种异型位点相连的基因似乎也可能影响麸质敏感性肠病的易感性。
Zotero 插件