淀粉样前体样蛋白APLP2的基因定位于人类染色体11q23 - q25。
The gene for the amyloid precursor-like protein APLP2 is assigned to human chromosome 11q23-q25.
作者信息
von der Kammer H, Löffler C, Hanes J, Klaudiny J, Scheit K H, Hansmann I
机构信息
Max-Planck-Institut für Biophysikalische Chemie, Abt. Molekulare Biologie, Göttingen, Germany.
出版信息
Genomics. 1994 Mar 15;20(2):308-11. doi: 10.1006/geno.1994.1174.
PMID:8020984
Abstract
The human amyloid precursor-like protein APLP2 is a highly conserved homologue of a sequence-specific DNA-binding mouse protein with a predicted function in the cell cycle. Somatic cell hybrids segregating human chromosomes were used to assign the APLP2 gene to chromosome 11. Fluorescence in situ hybridization confirmed this assignment and further localized the gene to q23-q25.
摘要
人类淀粉样前体样蛋白APLP2是一种与细胞周期中预测功能的序列特异性DNA结合小鼠蛋白高度保守的同源物。利用分离人类染色体的体细胞杂种将APLP2基因定位于11号染色体。荧光原位杂交证实了这一定位，并进一步将该基因定位到q23-q25。
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