Behnke J M, Rose R, Little J
Department of Life Science, University of Nottingham, U.K.
Int J Parasitol. 1994 Feb;24(1):91-101. doi: 10.1016/0020-7519(94)90062-0.
Experiments were carried out to ascertain whether the acute inflammatory phase of the intestinal response of hamsters to infection with Trichinella spiralis would adversely affect hookworms in concurrently infected animals. The survival and growth of hookworms were unaffected. However, the presence of hookworms reduced the establishment of T. spiralis, the initial growth of female worms and their fecundity. The expulsion of T. spiralis was also significantly slower in concurrently infected animals and there was significant depression of the serum IgG antibody response to muscle stage and adult worm antigens of T. spiralis in concurrently infected animals. These results are discussed in relation to the chronicity of human hookworm infections.
开展了实验以确定仓鼠对旋毛虫感染的肠道反应急性期是否会对同时感染的动物体内的钩虫产生不利影响。钩虫的存活和生长未受影响。然而，钩虫的存在减少了旋毛虫的定植、雌虫的初始生长及其繁殖力。在同时感染的动物中，旋毛虫的排出也明显较慢，并且同时感染的动物对旋毛虫肌肉期和成虫抗原的血清IgG抗体反应显著降低。结合人类钩虫感染的慢性情况对这些结果进行了讨论。
