头癣：伊曲康唑治疗断发毛癣菌感染
Tinea capitis: itraconazole in Trichophyton tonsurans infection.
作者信息
Elewski B E
机构信息
Case Western Reserve University, University Hospitals of Cleveland, OH 44106.
出版信息
J Am Acad Dermatol. 1994 Jul;31(1):65-7. doi: 10.1016/s0190-9622(94)70137-7.
BACKGROUND
Although griseofulvin is considered the standard treatment of tinea capitis, alternatives are being investigated in hopes of identifying more rapid and better cure rates.
OBJECTIVE
Our purpose was to determine the efficacy of itraconazole as therapy for tinea capitis.
METHODS
An open label study was performed on three patients who did not respond to or could not tolerate griseofulvin therapy.
RESULTS
A 30-day course of 100 mg of itraconazole daily resulted in clinical and mycologic cure in all three patients; no side effects were reported.
CONCLUSION
Although these results need to be confirmed by larger, controlled trials, it appears that itraconazole offers a viable alternative to griseofulvin for the treatment of children with tinea capitis.
背景
尽管灰黄霉素被认为是头癣的标准治疗方法，但人们正在研究其他替代方法，以期找到治愈率更高、速度更快的治疗方案。
目的
我们的目的是确定伊曲康唑治疗头癣的疗效。
方法
对三名对灰黄霉素治疗无反应或不耐受的患者进行了一项开放标签研究。
结果
三名患者每日服用100毫克伊曲康唑，疗程30天，均实现了临床和真菌学治愈；未报告有副作用。
结论
尽管这些结果需要通过更大规模的对照试验来证实，但伊曲康唑似乎为治疗儿童头癣提供了一种可行的灰黄霉素替代方案。
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