Montgomery S A, Roberts A, Patel A G
St Mary's Hospital Medical School, London, UK.
Int Clin Psychopharmacol. 1994 Mar;9 Suppl 1:49-53. doi: 10.1097/00004850-199403001-00008.
All episodes of depression require treatment after symptomatic response of the acute episode in order to consolidate response. If treatment is discontinued early, 30% to 50% of patients will suffer a relapse of the inadequately treated episode. Placebo-controlled studies with a variety of antidepressants, old and new, have provided compelling evidence of the efficacy of anti-depressants on relapse prevention. A recent study of citalopram has also shown the need for long-term treatment with anti-depressants in patients whose acute episode of depression appeared to respond to placebo since their response was not maintained.
所有抑郁发作在急性发作出现症状缓解后都需要进行治疗以巩固疗效。如果过早停药，30%至50%的患者会出现治疗不充分发作的复发。使用多种新旧抗抑郁药进行的安慰剂对照研究提供了令人信服的证据，证明抗抑郁药在预防复发方面的疗效。最近一项关于西酞普兰的研究还表明，对于那些急性抑郁发作似乎对安慰剂有反应但反应未持续的患者，需要长期使用抗抑郁药进行治疗。
