一名神经梅毒患者发生的雅-赫反应。
Jarisch-Herxheimer reaction in a patient with neurosyphilis.
作者信息
Zifko U, Lindner K, Wimberger D, Volc B, Grisold W
机构信息
Department of Neurology, Kaiser Franz Josef Spital, Vienna, Austria.
出版信息
J Neurol Neurosurg Psychiatry. 1994 Jul;57(7):865-7. doi: 10.1136/jnnp.57.7.865.
Abstract
A 40 year old man presented with progressive personality changes in the previous six months. Specific serological tests for syphilis in blood and CSF were highly positive and CSF sedimentation showed signs of an inflammatory process. Ten hours after the start of penicillin treatment a severe symptomatic Jarisch-Herxheimer reaction with alteration of level of consciousness, pupillary changes, and focal neurological signs developed. Jarisch-Herxheimer reaction may occur in various settings, particularly in the treatment of syphilis. Investigation of CSF before the treatment may predict a potential risk. Corticosteroid treatment has been suggested for prevention.
摘要
一名40岁男性在过去6个月中出现进行性人格改变。血液和脑脊液中梅毒的特异性血清学检测呈强阳性，脑脊液沉降显示有炎症过程的迹象。青霉素治疗开始10小时后，出现了严重的症状性吉海反应，伴有意识水平改变、瞳孔变化和局灶性神经体征。吉海反应可能在各种情况下发生，尤其是在梅毒治疗中。治疗前对脑脊液进行检查可能预测潜在风险。有人建议使用皮质类固醇进行预防。
相似文献
1
Jarisch-Herxheimer reaction in a patient with neurosyphilis.一名神经梅毒患者发生的雅-赫反应。
J Neurol Neurosurg Psychiatry. 1994 Jul;57(7):865-7. doi: 10.1136/jnnp.57.7.865.
2
A case of neurosyphilis with a florid Jarisch-Herxheimer reaction.一例伴有明显雅里希-赫克斯海默反应的神经梅毒病例。
J Clin Neurosci. 2002 Nov;9(6):689-90. doi: 10.1054/jocn.2002.1129.
3
Generalized Convulsive Status Epilepticus Secondary to Jarisch-Herxheimer Reaction in Neurosyphilis: A Case Report and Literature Review.神经梅毒中Jarisch-Herxheimer反应继发的全身惊厥性癫痫持续状态：一例报告及文献综述
Neurologist. 2019 Jan;24(1):29-32. doi: 10.1097/NRL.0000000000000219.
4
Jarisch-Herxheimer reaction in a patient with neurosyphilis: non-convulsive status epilepticus?一名神经梅毒患者发生的赫克斯海默反应：非惊厥性癫痫持续状态？
J Neurol Neurosurg Psychiatry. 1995 Apr;58(4):521. doi: 10.1136/jnnp.58.4.521-a.
5
Nonconvulsive status epilepticus resulting from Jarisch-Herxheimer reaction in a patient with neurosyphilis.一名神经梅毒患者因吉海反应导致非惊厥性癫痫持续状态。
Clin Electroencephalogr. 2000 Jul;31(3):138-40. doi: 10.1177/155005940003100306.
6
Penicillin-induced Jarisch-Herxheimer reaction.青霉素诱发的雅里希-赫克斯海默反应。
Ann Pharmacother. 2005 Dec;39(12):2128-30. doi: 10.1345/aph.1G308. Epub 2005 Nov 15.
7
Neurosyphilis and the Jarisch-Herxheimer reaction: A therapy concern with HIV disease.神经梅毒与雅-赫反应：艾滋病治疗中的一个问题。
Dermatol Ther. 2021 Mar;34(2):e14839. doi: 10.1111/dth.14839. Epub 2021 Feb 15.
8
Olanzapine treatment in Jarisch-Herxheimer reaction due to neurosyphilis with dementia: a case report.奥氮平治疗神经梅毒伴痴呆的贾第虫赫克斯海默反应：病例报告。
J Psychopharmacol. 2009 Nov;23(8):999-1000. doi: 10.1177/0269881108093585. Epub 2008 Jul 17.
9
Elevated CSF cytokines in the Jarisch-Herxheimer reaction of general paresis.麻痹性痴呆 Jarisch-Herxheimer 反应时脑脊液细胞因子升高。
JAMA Neurol. 2013 Aug;70(8):1060-4. doi: 10.1001/jamaneurol.2013.2120.
10
[Effect of corticosteroids on the Jarisch-Herxheimer reaction].[皮质类固醇对雅里希-赫克斯海默反应的影响]
Wien Klin Wochenschr. 1971 Mar 26;83(12):208-12.
引用本文的文献
1
An observational prospective study based on a large cohort of HIV-negative neurosyphilis patients with particular reference to the Jarisch-Herxheimer reaction.一项基于大量 HIV 阴性神经梅毒患者的观察性前瞻性研究，特别提到了贾里什-赫克斯海默反应。
Eur J Clin Microbiol Infect Dis. 2024 Jun;43(6):1073-1080. doi: 10.1007/s10096-024-04810-1. Epub 2024 Apr 1.
2
Neurosyphilis: insights into its pathogenesis, susceptibility, diagnosis, treatment, and prevention.神经梅毒：对其发病机制、易感性、诊断、治疗及预防的见解
Front Neurol. 2024 Jan 11;14:1340321. doi: 10.3389/fneur.2023.1340321. eCollection 2023.
3
Gummatous Neurosyphilis With Transient Worsening of Neurological Symptoms After Treatment Initiation.治疗开始后出现神经症状短暂加重的树胶肿性神经梅毒
Neurohospitalist. 2023 Oct;13(4):403-405. doi: 10.1177/19418744231175564. Epub 2023 May 10.
4
Clinical Presentation of Laboratory Confirmed Neurosyphilis in a Recent Cases Series.近期病例系列中实验室确诊的神经梅毒的临床表现
Clin Neuropsychiatry. 2019 Feb;16(1):17-24.
5
Epilepsy and syphilis: A systematic review and meta-analysis.癫痫与梅毒：系统评价与荟萃分析。
Indian J Dermatol Venereol Leprol. 2021;87(4):483-490. doi: 10.25259/IJDVL_681_19.
6
The Eye as a Window to Systemic Infectious Diseases: Old Enemies, New Imaging.眼睛作为全身感染性疾病的窗口：老对手，新成像技术
J Clin Med. 2019 Sep 5;8(9):1392. doi: 10.3390/jcm8091392.
7
The Jarisch-Herxheimer Reaction After Antibiotic Treatment of Spirochetal Infections: A Review of Recent Cases and Our Understanding of Pathogenesis.抗生素治疗螺旋体感染后的雅里希-赫克斯海默反应：近期病例回顾及我们对发病机制的理解
Am J Trop Med Hyg. 2017 Jan 11;96(1):46-52. doi: 10.4269/ajtmh.16-0434. Epub 2016 Oct 24.
8
Stroke after Initiating IV Penicillin for Neurosyphilis: A Possible Jarisch-Herxheimer Reaction.开始静脉注射青霉素治疗神经梅毒后发生的中风：一种可能的吉海反应。
Case Rep Neurol Med. 2014;2014:548179. doi: 10.1155/2014/548179. Epub 2014 Nov 5.
9
Deterioration of MRI findings related to Jarisch-Herxheimer reaction in a patient with neurosyphilis.一名神经梅毒患者中与雅里希-赫克斯海默反应相关的MRI表现恶化
J Neurol. 2011 Apr;258(4):699-701. doi: 10.1007/s00415-010-5808-9. Epub 2010 Nov 2.
10
Jarisch-Herxheimer reaction in a patient with neurosyphilis: non-convulsive status epilepticus?一名神经梅毒患者发生的赫克斯海默反应：非惊厥性癫痫持续状态？
J Neurol Neurosurg Psychiatry. 1995 Apr;58(4):521. doi: 10.1136/jnnp.58.4.521-a.
本文引用的文献
1
The production of Herxheimer reactions by injection of immune serum in rabbits with experimental syphilis.通过给患有实验性梅毒的兔子注射免疫血清引发赫克斯海默反应。
Am J Syph Gonorrhea Vener Dis. 1951 Sep;35(5):405-10.
2
Acute syphilitic optic neuritis.急性梅毒性视神经炎
Arch Ophthalmol. 1981 Aug;99(8):1392-5. doi: 10.1001/archopht.1981.03930020266010.
3
Jarisch-Herxheimer reaction in meningococcal meningitis.脑膜炎球菌性脑膜炎中的雅里施－赫克斯海默反应。
Am J Dis Child. 1983 Jun;137(6):599. doi: 10.1001/archpedi.1983.02140320075018.
4
Periodic EEG pattern in meningovascular syphilis.脑膜血管梅毒中的周期性脑电图模式。
J Neurol Neurosurg Psychiatry. 1984 Dec;47(12):1360-1. doi: 10.1136/jnnp.47.12.1360.
5
Jarisch-Herxheimer reaction in falciparum malaria?恶性疟中的雅里希-赫克斯海默反应？
Br Med J (Clin Res Ed). 1984 Jul 21;289(6438):161. doi: 10.1136/bmj.289.6438.161.
6
Endogenous opioid withdrawal in the Jarisch-Herxheimer reaction.雅里希-赫克斯海默反应中的内源性阿片类物质戒断
Lancet. 1983 May 21;1(8334):1135-6. doi: 10.1016/s0140-6736(83)92869-6.
7
Meptazinol diminishes the Jarisch-Herxheimer reaction of relapsing fever.美普他酚可减轻回归热的赫氏反应。
Lancet. 1983 Apr 16;1(8329):835-9. doi: 10.1016/s0140-6736(83)91384-3.
8
[Effect of encorton on the Lukasiewicz-Jarisch-Herxheimer reaction].[恩考顿对卢卡西维茨-雅里什-赫克斯海默反应的影响]
Przegl Dermatol. 1969 May-Jun;56(3):305-10.
9
Pseudoperiodic lateralized paroxysmal discharges in electroencephalogram.脑电图中的假性周期性一侧性阵发性放电
Neurology. 1971 Oct;21(10):975-81. doi: 10.1212/wnl.21.10.975.
10
The febrile response to treatment in Gambian sleeping sickness.冈比亚昏睡病治疗中的发热反应。
Ann Trop Med Parasitol. 1972 Mar;66(1):7-14. doi: 10.1080/00034983.1972.11686792.
Zotero 插件