Hatano Y, Hatano A
Chub Women's College, Gifu-Ken, Japan.
J Toxicol Environ Health. 1994 Jul;42(3):357-64. doi: 10.1080/15287399409531885.
Incubation of chicken embryos with either 0.01 or 0.03 ppm polychlorinated biphenyls (PCBs) for 12, 15, or 18 d resulted in a significant decrease in liver and body weight associated with enhanced mortality. Teratological examination revealed an increased frequency of malformations including hydrops, eventration, wry neck, and brevicollis. PCB exposure was also found to produce histologic damage to liver and cutaneous tissue. Our data demonstrate that exposure of chicks to PCBs during development results in a retardation of growth, an increased incidence of malformations, and histopathologic damage.
用0.01 ppm或0.03 ppm多氯联苯（PCBs）孵化鸡胚12、15或18天，会导致肝脏和体重显著下降，并伴有死亡率升高。畸形学检查显示畸形频率增加，包括水肿、腹壁裂、歪脖和短颈。还发现PCB暴露会对肝脏和皮肤组织造成组织学损伤。我们的数据表明，雏鸡在发育过程中接触PCBs会导致生长迟缓、畸形发生率增加和组织病理学损伤。
