Lanza D C, Deems D A, Doty R L, Moran D, Crawford D, Rowley J C, Sajjadian A, Kennedy D W
Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania Medical School, Philadelphia.
Laryngoscope. 1994 Jul;104(7):837-40. doi: 10.1288/00005537-199407000-00010.
Normal human olfactory function is subject to a wide variety of factors. Although biopsy of human olfactory neuroepithelium has been reported by several researchers, there are no studies which have evaluated the effect of this procedure on olfactory function. In this retrospective study, we sought to determine if tissue removal from the olfactory cleft has an adverse influence on the sense of smell. Nineteen subjects underwent bilateral olfactory testing and subsequent endoscopic olfactory mucosal biopsy. All subjects were retested 6 weeks to 1 year after olfactory neuroepithelial biopsy. No statistical difference was found between olfactory tests performed before or after biopsy. These data suggest that biopsy of human olfactory neuroepithelium has no discernible adverse effect on the ability to smell.
正常人类嗅觉功能受多种因素影响。尽管有几位研究者报告了人类嗅神经上皮活检情况，但尚无研究评估该操作对嗅觉功能的影响。在这项回顾性研究中，我们试图确定从嗅裂取出组织是否会对嗅觉产生不利影响。19名受试者接受了双侧嗅觉测试及随后的内镜下嗅黏膜活检。所有受试者在嗅神经上皮活检后6周至1年进行了重新测试。活检前后进行的嗅觉测试之间未发现统计学差异。这些数据表明，人类嗅神经上皮活检对嗅觉能力没有明显的不利影响。
