Rasheed F N
Laboratory Science Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka.
Med Hypotheses. 1994 Feb;42(2):76-80. doi: 10.1016/0306-9877(94)90079-5.
The proposed hypothesis suggests that the types of infections commonly experienced in pregnancy and in childhood are linked. The suggestion is made that maternal infections leave an impression on the developing fetal immune system and modulate future responsiveness to infection and/or vaccination challenge. A number of factors are explored which may influence this process, namely immunoregulation in pregnancy and infection type, gestation, maturity of the fetal immune system, and parity.
提出的假说表明,孕期和儿童期常见的感染类型存在关联。有人提出,母体感染会给发育中的胎儿免疫系统留下印记,并调节未来对感染和/或疫苗接种挑战的反应性。本文探讨了一些可能影响这一过程的因素,即孕期免疫调节、感染类型、孕周、胎儿免疫系统成熟度和产次。