[中老年慢性特发性多发性神经病的病程：2年随访研究]
[Course of chronic idiopathic polyneuropathy during middle age and older: 2-year follow-up study].
作者信息
Notermans N C, Wokke J H, Franssen H, Vermeulen M, Busch H F, Jennekens F G
机构信息
Afd. Neurologie, Academisch Ziekenhuis, Utrecht.
出版信息
Ned Tijdschr Geneeskd. 1994 Jun 18;138(25):1281-5.
OBJECTIVE
To study the clinical features and natural course of idiopathic polyneuropathy.
DESIGN
Prognostic and descriptive cohort study.
SETTING
University Hospital, Utrecht, the Netherlands.
METHOD
75 patients (46 men, 29 women) with a mean age of 56.5 years at onset of symptoms were clinically investigated during two years.
RESULTS
The features of chronic idiopathic polyneuropathy were heterogeneous. Clinically, 44 patients had a sensorimotor, 29 patients a sensory and 2 patients a motor polyneuropathy. Electrophysiological and nerve biopsy studies were compatible with an axonal polyneuropathy. The overall clinical course was slowly progressive. None of the patients became severely disabled. After one year of follow up one patient proved to have a hereditary neuropathy. In the other 74 patients no cause for the polyneuropathy was found even after 2 years of follow-up.
CONCLUSION
Chronic idiopathic polyneuropathy is a heterogeneous entity, leading to only slight disability. The neuropathy is due to axonal degeneration.
目的
研究特发性多发性神经病的临床特征及自然病程。
设计
预后及描述性队列研究。
地点
荷兰乌得勒支大学医院。
方法
对75例症状发作时平均年龄为56.5岁的患者（46例男性，29例女性）进行了为期两年的临床研究。
结果
慢性特发性多发性神经病的特征具有异质性。临床上，44例患者为感觉运动型，29例患者为感觉型，2例患者为运动型多发性神经病。电生理和神经活检研究结果与轴索性多发性神经病相符。总体临床病程呈缓慢进展。无患者出现严重残疾。随访一年后，1例患者被证实患有遗传性神经病。在其他74例患者中，即使经过2年随访，也未发现多发性神经病的病因。
结论
慢性特发性多发性神经病是一种异质性疾病，仅导致轻微残疾。该神经病是由轴突变性引起的。
Zotero 插件