Wokke J H, Notermans N C
Academisch Ziekenhuis, afd. Neurologie, Utrecht.
Ned Tijdschr Geneeskd. 1997 Nov 29;141(48):2321-4.
So many conditions, both hereditary and acquired, can lead to polyneuropathy that a systematic approach is needed to identify the cause. Finding a cause is necessary to inform the patient about prognosis, handicap and chances of treatment. Three patients with polyneuropathy are described. The first was a man aged 34 with a predominantly motor neuropathy who appeared to have a duplication in the pmp-22 gene on chromosome 17PII.2. The diagnosis was hereditary sensorimotor neuropathy type IA (hypertrophic form of Charcot-Marie-Tooth disease). The second was a woman of 58 years; she had a sensory polyneuropathy as the first manifestation of Hodgkin's disease. The last patient, a 67-year-old man, had polyneuropathy due to vasculitis. He showed a prompt response to treatment.
许多遗传性和后天性疾病都可导致多发性神经病，因此需要采用系统的方法来确定病因。找出病因对于告知患者预后、残疾情况及治疗机会至关重要。本文描述了三名多发性神经病患者。第一名患者是一名34岁男性，主要表现为运动神经病，其17号染色体PII.2上的pmp - 22基因似乎存在重复。诊断为遗传性感觉运动神经病IA型（肥厚型夏科 - 马里 - 图斯病）。第二名患者是一名58岁女性，她的感觉性多发性神经病是霍奇金病的首发表现。最后一名患者是一名67岁男性，因血管炎导致多发性神经病。他对治疗反应迅速。
